Interleukin-27 directly induces differentiation in hematopoietic stem cells

blood2008cover.gif

Jun Seita, Masayuki Asakawa, Jun Ooehara, Shin-ichiro Takayanagi, Yohei Morita, Nobukazu Watanabe, Koji Fujita, Motoshige Kudo, Junichiro Mizuguchi, Hideo Ema, Hiromitsu Nakauchi, and Takayuki Yoshimoto

Blood First Edition Paper, prepublished online November 27, 2007; DOI 10.1182/blood-2007-06-093328

Abstract on Blood Website

November 27, 2007 | Permalink

Hematopoietic Stem Cell Quiescence Attenuates DNA Damage Response and Permits DNA Damage Accumulation During Aging.

CoverCC6-19.jpg

Rossi DJ, Seita J, Czechowicz A, Bhattacharya D, Bryder D, Weissman IL.

Cell Cycle 2007 Jul 18;6(19)

PubMed

July 18, 2007 | Permalink

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

nature2007.jpg

Derrick J. Rossi*, David Bryder*, Jun Seita, Andre Nussenzweig, Jan Hoeijmakers & Irving L. Weissman (*:equally contributed).

Nature 447, 725-729 (7 June 2007).

PubMed

Full Text (Nature account required)

June 6, 2007 | Permalink

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

PNAS2007.gif

Seita J, Ema H, Ooehara J, Yamazaki S, Tadokoro Y, Yamasaki A, Eto K, Takaki S, Takatsu K, Nakauchi H.

Proc Natl Acad Sci U S A 104 (7) :2349-54 (2007).

February 6, 2007 | Permalink

Adult mouse hematopoietic stem cells: purification and single-cell assays

NatProt2007.gif

Ema H, Morita Y, Yamazaki S, Matsubara A, Seita J, Tadokoro Y, Kondo H, Takano H, Nakauchi H.

Nature Protocols 1 :2979-87 (2007).

December 29, 2006 | Permalink

Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice.

devcell8.jpg

Ema H, Sudo K, Seita J, Matsubara A, Morita Y, Osawa M, Takatsu K, Takaki S, Nakauchi H.

Dev Cell 8 (6) :907-14 (2005).

June 9, 2005 | Permalink