Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.

gene_dev.gif

Inlay MA, Bhattacharya D, Sahoo D, Serwold T, Seita J, Karsunky H, Plevritis SK, Dill DL, Weissman IL.

Genes Dev. 2009 Oct 15;23(20):2376-81.

PubMed

October 15, 2009 | Permalink

Establishment of a Normal Hematopoietic and Leukemia Stem Cell Hierarchy.

CoverCSHL.jpg

Chao MP, Seita J, Weissman IL.

Cold Spring Harb Symp Quant Biol. 2008 Nov 6. [Epub ahead of print]

PubMed

November 6, 2008 | Permalink

Interleukin-27 directly induces differentiation in hematopoietic stem cells.

blood2008cover.gif

Jun Seita, Masayuki Asakawa, Jun Ooehara, Shin-ichiro Takayanagi, Yohei Morita, Nobukazu Watanabe, Koji Fujita, Motoshige Kudo, Junichiro Mizuguchi, Hideo Ema, Hiromitsu Nakauchi, and Takayuki Yoshimoto

Blood. 2008 Feb 15;111(4):1903-12. Epub 2007 Nov 27.

PubMed

November 27, 2007 | Permalink

Hematopoietic Stem Cell Quiescence Attenuates DNA Damage Response and Permits DNA Damage Accumulation During Aging.

CoverCC6-19.jpg

Rossi DJ, Seita J, Czechowicz A, Bhattacharya D, Bryder D, Weissman IL.

Cell Cycle 2007 Jul 18;6(19)

PubMed

July 18, 2007 | Permalink

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

nature2007.jpg

Derrick J. Rossi*, David Bryder*, Jun Seita, Andre Nussenzweig, Jan Hoeijmakers & Irving L. Weissman (*:equally contributed).

Nature 447, 725-729 (7 June 2007).

PubMed

Full Text (Nature account required)

June 6, 2007 | Permalink

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

PNAS2007.gif

Seita J, Ema H, Ooehara J, Yamazaki S, Tadokoro Y, Yamasaki A, Eto K, Takaki S, Takatsu K, Nakauchi H.

Proc Natl Acad Sci U S A 104 (7) :2349-54 (2007).

PubMed

February 6, 2007 | Permalink

Adult mouse hematopoietic stem cells: purification and single-cell assays.

NatProt2007.gif

Ema H, Morita Y, Yamazaki S, Matsubara A, Seita J, Tadokoro Y, Kondo H, Takano H, Nakauchi H.

Nature Protocols 1 :2979-87 (2007).

PubMed

December 29, 2006 | Permalink

Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice.

devcell8.jpg

Ema H, Sudo K, Seita J, Matsubara A, Morita Y, Osawa M, Takatsu K, Takaki S, Nakauchi H.

Dev Cell 8 (6) :907-14 (2005).

PubMed

June 9, 2005 | Permalink