Jun Seita's Web

Interleukin-27 directly induces differentiation in hematopoietic stem cells

Jun Seita, Masayuki Asakawa, Jun Ooehara, Shin-ichiro Takayanagi, Yohei Morita, Nobukazu Watanabe, Koji Fujita, Motoshige Kudo, Junichiro Mizuguchi, Hideo Ema, Hiromitsu Nakauchi, and Takayuki Yoshimoto

Blood First Edition Paper, prepublished online November 27, 2007; DOI 10.1182/blood-2007-06-093328

Abstract on Blood Website

November 27, 2007 | Permalink

Hematopoietic Stem Cell Quiescence Attenuates DNA Damage Response and Permits DNA Damage Accumulation During Aging.

Rossi DJ, Seita J, Czechowicz A, Bhattacharya D, Bryder D, Weissman IL.

Cell Cycle 2007 Jul 18;6(19)

PubMed

July 18, 2007 | Permalink

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

Derrick J. Rossi^*, David Bryder^*, Jun Seita, Andre Nussenzweig, Jan Hoeijmakers & Irving L. Weissman (^*:equally contributed).

Nature 447, 725-729 (7 June 2007).

PubMed

Full Text (Nature account required)

June 6, 2007 | Permalink

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

Seita J, Ema H, Ooehara J, Yamazaki S, Tadokoro Y, Yamasaki A, Eto K, Takaki S, Takatsu K, Nakauchi H.

Proc Natl Acad Sci U S A 104 (7) :2349-54 (2007).

February 6, 2007 | Permalink

Adult mouse hematopoietic stem cells: purification and single-cell assays

Ema H, Morita Y, Yamazaki S, Matsubara A, Seita J, Tadokoro Y, Kondo H, Takano H, Nakauchi H.

Nature Protocols 1 :2979-87 (2007).

December 29, 2006 | Permalink

Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice.

Ema H, Sudo K, Seita J, Matsubara A, Morita Y, Osawa M, Takatsu K, Takaki S, Nakauchi H.

Dev Cell 8 (6) :907-14 (2005).

June 9, 2005 | Permalink