MiDReG: A method of mining developmentally regulated genes using Boolean implications.

Sahoo D, Seita J, Bhattacharya D, Inlay MA, Weissman IL, Plevritis SK, and Dill DL.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5732-7. Epub 2010 Mar 15.

PMID: 20231483

Press release from Stanford

Parameter 2009 2010 2011 2012 2013 2014 2015 2016 2017
Times Cited 0 4 4 3 3 1 0 0
2-year Impact Factor 9.435 9.771 9.681 9.737 9.809 9.674 9.423 9.661
5-year Impact Factor 10.312 10.591 10.472 10.583 10.727 10.563 10.285 10.414

Light yellow : Journal's impact factor was outperformed by the citation of the paper.

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Personally, this is a mile-stone publication for me. In 2006, before I came to Stanford, at the Keystone symposia "Signaling Networks", I realized that the future of biology is in systems approach. Since then, I've been seeking how to connect real stem cell biology to systems approach. In 2007 I met Debashis Sahoo at a small meeting on the campus called "Biomedical Computation at Stanford. He has been thinking how to connect systems approach to real biology. Then we initiated this project, and succeeded with collaborators. This article describes logical part, and the companion paper Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. describes the biology part. Since this is an example of the connection, this is just a beginning.

March 15, 2010

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