MiDReG: A method of mining developmentally regulated genes using Boolean implications.
Sahoo D, Seita J, Bhattacharya D, Inlay MA, Weissman IL, Plevritis SK, and Dill DL.
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5732-7. Epub 2010 Mar 15.
|2-year Impact Factor||9.435||9.771||9.681||9.737||9.809||9.674||9.423|
|5-year Impact Factor||10.312||10.591||10.472||10.583||10.727||10.563||10.285|
Light yellow : Journal's impact factor was outperformed by the citation of the paper.
Personally, this is a mile-stone publication for me. In 2006, before I came to Stanford, at the Keystone symposia "Signaling Networks", I realized that the future of biology is in systems approach. Since then, I've been seeking how to connect real stem cell biology to systems approach. In 2007 I met Debashis Sahoo at a small meeting on the campus called "Biomedical Computation at Stanford. He has been thinking how to connect systems approach to real biology. Then we initiated this project, and succeeded with collaborators. This article describes logical part, and the companion paper Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. describes the biology part. Since this is an example of the connection, this is just a beginning.